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Get Drug Receptors and Their Effectors PDF

By N.J.M. Birdsall

ISBN-10: 1349055557

ISBN-13: 9781349055555

ISBN-10: 1349055573

ISBN-13: 9781349055579

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J. , 53, 308-10 Anderson, C. R. and Stevens, C. F. (1973). J. , 235,655-91 Begenisich, T. and Stevens, C. F. (1975). Biophys. , 15,843-6 Burgen, A. S. V. and Terroux, K. G. (1953). J. , 120,449-64 Castillo, J. del and Katz, B. (1957). Proc. R. Soc. B, 146,369-81 Colquhoun, D. (1971). Lectures on Biostatistics, Clarendon Press, Oxford Colquhoun, D. and Hawkes, A. G. (1977). Proc. R. Soc. B, 199,231-62 . , Noma, A. and Trautwein, W. (1980). , Peper, K. and Sterz, R. (1978). J. , 281,395-419 Dudel, J.

76, 5626-30 Blume, A. , Lichtshtein, D. and Boone, G. (1980). In Receptors for Neurotransmitters and Peptide Hormones (ed. C. C. Pepeu, M. J. Kuhar and S. J. Enna), Raven Press, New York, pp. 163-74 Blume, A. , Finberg, J. P. M. and Spector, S. (1977). Proc. natn. Acad. Sci. , 74,4927-31 Cassel, D. and Selinger, Z. (1976). Biochem. biophys. Acta, 452,538-51 Cassel, D. and Selinger, Z. (1977). Proc. natn. Acad. Sci. , 74,3307-11 Chang, R. S. L. and Snyder, S. H. (1980). J. Neurochem. 34,917-22 Childers, S.

1). None of these early studies with intact NG108·15 cells, cell homogenates or membranes indicated a co-operative nature to the binding or multiple forms of the binding site. , 1979a). With rat brain opiate binding, Na+ is known to affect agonist and antagonist binding differentially (Pert and Snyder, 1975). 2 :J A. B. 2 L!!..... O 6 ici 'O I 109 I 168 ~ ILl -£ 40 z "'-cu 20 E NoS! 1 Binding of [3H]Dala 2 met S NH 2 ENK to NG108-15 opiate receptors. Membranes suspended in buffer at 32°C for 20 min with increasing 3H-labelled peptide (A) or with 8 nM 3H-Iabelled peptide and various amounts of non-radioactive ligands (B).

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