By Fumio Hanaoka, Kaoru Sugasawa
This booklet is a complete assessment of the precise molecular mechanisms of and practical crosstalk one of the replication, recombination, and service of DNA (collectively referred to as the "3Rs") and the comparable strategies, with designated attention in their organic and scientific effects. The 3Rs are basic molecular mechanisms for organisms to keep up and infrequently deliberately adjust genetic details. DNA replication, recombination, and service, separately, were very important topics of molecular biology considering its emergence, yet we have now lately turn into acutely aware that the 3Rs are literally even more in detail concerning each other than we used to achieve. in addition, the 3R examine fields were growing to be much more interdisciplinary, with higher figuring out of molecular mechanisms underlying different very important methods, comparable to chromosome constructions and capabilities, mobilephone cycle and checkpoints, transcriptional and epigenetic law, etc. This e-book contains 7 elements and 21 chapters: half 1 (Chapters 1–3), DNA Replication; half 2 (Chapters 4–6), DNA Recombination; half three (Chapters 7–9), DNA fix; half four (Chapters 10–13), Genome Instability and Mutagenesis; half five (Chapters 14–15), Chromosome Dynamics and capabilities; half 6 (Chapters 16–18), mobile Cycle and Checkpoints; half 7 (Chapters 19–21), interaction with Transcription and Epigenetic rules. This quantity should still allure the good curiosity of graduate scholars, postdoctoral fellows, and senior scientists in wide examine fields of easy molecular biology, not just the middle 3Rs, but in addition many of the comparable fields (chromosome, mobilephone cycle, transcription, epigenetics, and related areas). also, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and plenty of different fields will locate this ebook valuable.
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Additional resources for DNA Replication, Recombination, and Repair: Molecular Mechanisms and Pathology
2009; Cayrou et al. 2011, 2012), Drosophila melanogaster (Cayrou et al. 2011), human (Cadoret et al. 2008; Karnani et al. 2010; Mesner et al. 2011; Martin et al. 2011), and Arabidopsis thaliana genomes (Costas et al. 2011). In all these species, replication origins are located at precise sites along the genome. A relationship between CpG islands found at promoters of house-keeping genes and replication origins was identiﬁed in human cells (Delgado et al. 1998; Cadoret et al. 2008). Eukaryotic genomes, as with prokaryotes, display asymmetries in the prevalence of G/C over T/A bases in the leading and lagging replication strands.
Origin selection also changes dramatically during embryogenesis in concert with developmental signaling pathways. Dysregulation of origin positioning and recognition are implicated in human disease, as mutations in origin-binding proteins have been found in developmental disorders, and expansions in repeat-containing genomic regions promote genome instability. This chapter summarizes current understanding about replication origins, the most recent discoveries, and outlines key unanswered questions in this exciting ﬁeld.
Curr Biol 22(4):343–349. cub. 023 Wilson MA, Kwon Y, Xu Y, Chung WH, Chi P, Niu H, Mayle R, Chen X, Malkova A, Sung P, Ira G (2013) Pif1 helicase and Poldelta promote recombination-coupled DNA synthesis via bubble migration. Nature 502(7471):393–396. 1038/nature12585 Yabuuchi H, Yamada Y, Uchida T, Sunathvanichkul T, Nakagawa T, Masukata H (2006) Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins. EMBO J 25(19):4663–4674 Zegerman P, Difﬂey JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.
DNA Replication, Recombination, and Repair: Molecular Mechanisms and Pathology by Fumio Hanaoka, Kaoru Sugasawa