By Dhiraj Bhatia, Yamuna Krishnan (auth.), Volker A. Erdmann, Jan Barciszewski (eds.)
This booklet will offer most up-to-date insights within the useful potentials of ribonucleic acids in medine and using Spiegelmer and Spiegelzyme platforms. it is going to additionally care for a brand new kind of supply structures for mobile targeting.
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Extra info for DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases
2008). Coordination polymer nanobelts with AgNO3 and 4,40 -bipyridine shows decreased fluorescence upon interaction with ssDNA (Luo et al. 2011). DNA–silver nanoclusters have been shown to have increased red fluorescence upon interaction with G-rich oligonucleotides (Fig. 7; Yeh et al. 2010), thereby allowing the specific detection of G containing DNA targets. SsDNA-conjugated QDs have also been shown to have their fluorescence quenched by 40 % upon hybridization to complementary DNA (Lim et al.
Anal Chem 82:2759–2765 Tan YN, Su X, Zhu Y et al (2010b) Sensing of transcription factor through controlled-assembly of metal nanoparticles modified with segmented DNA elements. ACS Nano 4:5101–5110 Tan YN, Lee KH, Su X (2011) Study of single-stranded DNA binding protein-nucleic acids interactions using unmodified gold nanoparticles and its application for detection of single nucleotide polymorphisms. Anal Chem 83:4251–4257 Tan L, Neoh KG, Kang ET et al (2012) Affinity analysis of DNA aptamer-peptide interactions using gold nanoparticles.
CD has been especially amenable to studying DNA quadraplexes, which are important in the study of telomeres and cancer research (Paramasivan et al. 2007). While chirality is a characteristic of biomolecules, it is not ordinarily present in synthetic materials such as NPs. Nevertheless, when chiral biomolecules are attached to metallic NPs, a unique CD signal is observed, though the details of this phenomenon are still largely unknown (Gerard et al. 2011; Guerrero-Martinez et al. 2011; Li et al.
DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases by Dhiraj Bhatia, Yamuna Krishnan (auth.), Volker A. Erdmann, Jan Barciszewski (eds.)