Home Bioinformatics • Download PDF by Glyn Moody: Digital Code of Life: How Bioinformatics is Revolutionizing

Download PDF by Glyn Moody: Digital Code of Life: How Bioinformatics is Revolutionizing

By Glyn Moody

ISBN-10: 0471327883

ISBN-13: 9780471327882

A behind-the-scenes examine the main profitable self-discipline inside of biotechnologyBioinformatics represents a brand new sector of chance for traders and members. businesses are spending billions at the in all probability profitable items that may come from bioinformatics. This booklet appears at what businesses like Merck, Glaxo SmithKline Beecham, and Celera, and hospitals are doing to move themselves to management positions during this quarter. jam-packed with in-depth insights and superb revelations, electronic Code of lifestyles examines the personalities who've introduced bioinformatics to existence and explores the economic purposes and funding possibilities of the main profitable self-discipline inside of genomics.Glyn Moody (London, united kingdom) has released quite a few articles in stressed journal. he's the writer of the severely acclaimed e-book insurgent Code.

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A team led by Michael Waterfield at the Imperial Cancer Research Fund in London had been studying the same growth factor. qxd 12/3/03 3:21 PM Page 24 24 DIGITAL CODE OF LIFE comparing it with existing protein databases to search for homologies. S. National Institutes of Health. Lipman was working on molecular evolution and, together with John Wilbur, had come up with an early program for carrying out sequence comparisons against databases. The Wilbur-Lipman approach was important because it jettisoned the exact but computationally slow methods used by the Needleman-Wunsch and Smith-Waterman algorithm.

Undaunted, Doolittle himself regularly checked new protein structures as they were published against his growing database and that of Dayhoff in the hope that there might be some interesting homologies. On Saturday morning, May 28, 1983, he typed in two more sequences, both believed to be part of a protein involved in normal human cell growth. To Doolittle’s amazement, he not only found a match—he found something extraordinary. His sequence comparison program showed that the growth factor appeared closely related to parts of a gene found in a cancer-causing virus in monkeys.

Gilbert’s inarguable scientific prowess made an otherwise preposterous idea look at least possible. qxd 12/3/03 3:23 PM Page 39 GENOME DELIGHT 39 start-up before—the biotech company Biogen, founded in 1978—made it seem downright plausible. The ramifications were wide-ranging. Although Gilbert accepted that there was always the risk that someone else might emulate the company, he also noted that “once someone has done it, it is in no one else’s interest to do it again. ” As a result, if Genome Corporation succeeded, it would probably end up with a monopoly on the digital code underlying life.

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Digital Code of Life: How Bioinformatics is Revolutionizing Science, Medicine, and Business by Glyn Moody


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