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Otto Braun-Falco M.D., Stefan Lukacs M.D., Herbert's Dermatologic Radiotherapy PDF

By Otto Braun-Falco M.D., Stefan Lukacs M.D., Herbert Goldschmidt M.D. (auth.)

ISBN-10: 1461298806

ISBN-13: 9781461298809

ISBN-10: 1461298822

ISBN-13: 9781461298823

TO THE ENGLISH variation Ionizing radiation has performed a big position within the therapy of epidermis illnesses for plenty of a long time. With strict adherence to fashionable criteria of radiation security, radiotherapy is a secure and potent technique that merits many sufferers who can't be handled safely by means of different skill. even supposing symptoms for dermatologic radiotherapy have diminished considerably because of advances in different healing modalities, many dermatologists suppose strongly that ionizing radiation is a vital part of dermatologic treatment that are supposed to no longer be relinquished to different specialties due to the hugely really good anatomic, pathologic, and technologic wisdom required. a up to date survey of the nationwide application for Dermatology confirmed that forty four% of 2,444 responding dermatologists use radiotherapy usually for numerous epidermis stipulations, fairly within the remedy of cutaneous carcinomas. considerably, the yank Board of Dermatology has made up our minds to proceed its requirement of distinctive wisdom in dermatologic radiation remedy for board certification. simply because i've got taught this dermatologic subspecialty at quite a few degrees, either in Europe and within the usa, I with ease agreed to simply accept professional­ fessor Braun-Falco's invitation to cooperate with him and Dr. Lukacs within the guidance of the English version of this new consultant. The textual content bargains more often than not with sleek strategies of dermatologic radiotherapy and empha­ sizes sensible elements of therapy. even though it is written as an introduc­ tion for younger dermatologists, it might probably even be precious to skilled clinicians who are looking to stay alongside of contemporary advancements during this field.

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45 General Radiobiology Chemical Reactions WATER Radiation products of high biologic activity are those produced by activation of water (free H· and OH· radicals, hydrogen peroxide, and other chemically and biochemically active peroxides). Molecular oxygen plays an important part in their formation; the more O 2 , the more H 2 0 2 (FritzNiggli 1959). PROTEINS Roentgen rays may alter the configuration of proteins. Sulfhydril groups are a prominent target. The dosage required to cause such changes, however, is several thousand rads.

Cysteine) reduce it (for a literature review, see Franke 1972; Wiskemann 1972). In dermatologic practice, these substances are currently of no significant value. The degree of differentiation and the location of the irradiated tissue are important factors. The inguinal, axillary, and anal regions are more sensitive than the thorax, abdomen, or face. Temperature elevation increases radiosensitivity; so does an increased metabolic rate. Metabolic diseases, such as diabetes mellitus or gout, increase radiosensitivity of the skin; a similar effect is observed following administration of certain drugs, such as iodine.

FIRST-DEGREE ACUTE RADIODERMATITIS A first-degree reaction is characterized by erythema or hyperemia with edema. Pruritus may occur. The reaction reaches its maximum in 10-14 days, usually subsides in the third or fourth week. Pigmentation may persist for several weeks or months. Alopecia may be temporary or permanent, depending on the dosage. SECOND-DEGREE ACUTE RADIODERMATITIS There is no sharp line of demarcation between first-degree and seconddegree radiodermatitis. Intense erythema, edema, vesiculation, erosion, and superficial ulceration are the predominant symptoms (Figs.

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Dermatologic Radiotherapy by Otto Braun-Falco M.D., Stefan Lukacs M.D., Herbert Goldschmidt M.D. (auth.)


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