Home Nonfiction 10 • Dr. T. N. Chase, M. M. Mouradian, G. Fabbrini, J. L. Juncos's Continuous Dopaminergic Stimulation in Parkinson’s Disease: PDF

Dr. T. N. Chase, M. M. Mouradian, G. Fabbrini, J. L. Juncos's Continuous Dopaminergic Stimulation in Parkinson’s Disease: PDF

By Dr. T. N. Chase, M. M. Mouradian, G. Fabbrini, J. L. Juncos (auth.), Dr. J. A. Obeso, Dr. R. Horowski, Prof. Dr. C. D. Marsden (eds.)

ISBN-10: 3211820345

ISBN-13: 9783211820346

ISBN-10: 3709189543

ISBN-13: 9783709189542

At this assembly, a few severe teams proven and prolonged the unique findings via J.A. Obeso and his colleagues. those authors stumbled on that non-stop s.c. infusion of lisuride, a watersoluble dopaminergic eight- -aminoergoline with dopaminergic houses which might be injected or infused, can increase - occasionally relatively significantly - motor functionality in critically disabled fluctuating Parkinsonian sufferers. The concurrent use of the peripheral dopamine antagonist domperidone attenuates or prevents unwanted side effects regarding the stimulation of "peripheral" dopamine receptors, together with the chemoreceptor set off sector and a few parts of the hypothalamus outdoors the blood-brain barrier. The medical effects mentioned during this quantity would possibly not purely be a foundation for extra advancements in our wisdom and healing thoughts in Parkinsonism, they aspect to the to date overlooked significance of alternative methods of stimulating neurological or different platforms, e.g. discontinous, oscillatory results because of common oral software vs. non-stop stimulation as defined the following with the lisuride s.c. infusion. comparable techniques need to be mentioned and investigated in neurological problems. during this admire, this multidisciplinary assembly and its ebook may well supply new principles and ideas for treatment typically, as well as its strength program within the remedy of the problems of Parkinson's disease.

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Dr. T. N. Chase, M. M. Mouradian, G. Fabbrini, J. L. Juncos's Continuous Dopaminergic Stimulation in Parkinson’s Disease: PDF

At this assembly, a couple of severe teams proven and prolonged the unique findings through J. A. Obeso and his colleagues. those authors stumbled on that non-stop s. c. infusion of lisuride, a watersoluble dopaminergic eight- -aminoergoline with dopaminergic houses which are injected or infused, can increase - occasionally relatively significantly - motor functionality in critically disabled fluctuating Parkinsonian sufferers.

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Extra info for Continuous Dopaminergic Stimulation in Parkinson’s Disease: Proceedings of the Workshop in Alicante, Spain, September 22–24, 1986

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11 mg/ hour) had to be supplemented by oral L-dopa (at the minimum effective dose of200-1000mg plus DDI; Table 3). These patients displayed prolonged akinetic periods or delays in turning on not improvable by an increased lisuride infusion rate during the preceding 15 days. 57 hours on an average. In this group 2 patients out of 7 required a 24-hour regimen since both were severely akinetic in the morning and experienced considerable delays in turning on despite supplemental oral L-dopa. 055 mg/hour.

Stocchi et al. system to patients with Parkinson's disease and complicated responses to oral therapy. , 1986). , 1986). , 1986). Therefore, in this study the clinical effect of lisuride without oral L-dopa was tested using a 12-hour infusion regimen whenever possible, in order to avoid overdosage more likely to occur during a 24-hour course of application. , 1986). 2), with idiopathic Parkinson's disease (Hoehn and Yahr Rating Scale stage III to V) were studied. All were informed about the study and agreed to participate after full disclosure of its purpose, risks and potential benefits.

In contrast, the severity of the disease assessed in a single patient demanding a 24-hour infusion regimen of lisuride without L-dopa was comparable to that of the other members of his group. 5 Control Off status (hours) 2 1 3 2 2 2 2 AIMs 24 24 12 12 12 12 12 Infusion regimen (hours) 24 12 12 12 12 12 5 4 5 3 4 0 0 1 1 0 15 12 3 1 9 Control Infusion regimen (hours) Months of treatment Infusion Off status (hours) Table 3. 065 I 2 3 4 6 Patient Lisuride mg/hours Patient Table 2. en S· (1) 0.. ::l.

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Continuous Dopaminergic Stimulation in Parkinson’s Disease: Proceedings of the Workshop in Alicante, Spain, September 22–24, 1986 by Dr. T. N. Chase, M. M. Mouradian, G. Fabbrini, J. L. Juncos (auth.), Dr. J. A. Obeso, Dr. R. Horowski, Prof. Dr. C. D. Marsden (eds.)


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