By Luca Escoffier, Mario Ganau, Julielynn Wong
The nanotechnology is a fast-growing zone with a tremendous power for novel purposes and brilliant gains, however it is dealing with a tough second end result of the present turmoil and the doubts raised by means of these calling for a moratorium in examine actions so long as the doubtless antagonistic results of this self-discipline usually are not totally ascertained.
The booklet starts off with an intensive creation to nanotechnology and nanomedicine and their investment assets. as soon as the contours of the subject material are pointed out, a scrutiny of the laws at present acceptable to nanotechnology and nanomedicine is performed including the exam of the highbrow estate rights that may be envisaged to guard and valorize the acknowledged techniques. using patents and different workable routes are thought of, including the present valuation tools, which exhibit how a quantitative valuation during this box isn't really plausible. The examine duly considers the monetization of recommendations via traditional and nonconventional options like advert hoc projects, auctions, and brokerage.
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Additional resources for Commercializing nanomedicine : industrial applications, patents, and ethics
The advances in micro- and nanofabrication technologies have enabled the preparation of increasingly smaller mechanical transducers, so nowadays a promising family of biosensors is represented by micro- and nanomechanical systems, which are basically cantilever-like sensors: they are particularly well matched in size with molecular interactions and provide a basis for biological probes with single-molecule sensitivity, indeed [28, 29]. Recently, 02-Luca-Escoﬃer-02 37 July 24, 2015 18:13 PSP Book - 9in x 6in 38 Diagnostic Challenges of Nanomedicine detection of mass in the zeptogram range and sensitivity in liquid to the fraction of nM concentration in real time has been demonstrated .
In particular they interrogated the activity associated with PI3K signaling in a model of glioma cancer (U87 cells line) as a function of cell–cell separation: their results indicated that only a subpopulation of cells presented a constitutive activation of EGFR, while the majority did not. This ﬁnding conﬁrmed that such approach allows not only for a thorough quantitative in vitro analysis of the proteome of few living cells but also for a simulation of their hypothetical behavior in vivo: In line with the hypothesis that the expression of EGFR in a subpopulation of cells represents a trigger for parenchymal invasion, its expression in the majority or the entirety 43 July 24, 2015 18:13 PSP Book - 9in x 6in 44 Diagnostic Challenges of Nanomedicine of the tumor would not enhance tumorigenicity but instead would create a self-inhibiting state.
Another important factor on obtaining high-resolution prints at the 100 nm level relates with the ink utilized; to this regard biomolecules are attractive nanocontact printing inks since their high molecular weight prevents diﬀusion during the printing step, resulting in highresolution features. As opposed to the parallel conventional photolithographic process, nanocontact printing is not diﬀraction limited and makes it possible to pattern surfaces with molecular-sized features. A signiﬁcant advantage of nanocontact printing lithography compared to serial techniques such as DPN is that large areas can be nanopatterned rapidly.
Commercializing nanomedicine : industrial applications, patents, and ethics by Luca Escoffier, Mario Ganau, Julielynn Wong