By Hans Scheurlen (auth.), H. R. Scheurlen, G. Weckesser, I. Armbruster (eds.)
Read or Download Clinical Trials in ‘Early’ Breast Cancer: Methodological and Clinical Aspects of Treatment Comparisons Proceedings of a Symposium, Heidelberg, Germany, 4th to 8th December, 1978 PDF
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Additional resources for Clinical Trials in ‘Early’ Breast Cancer: Methodological and Clinical Aspects of Treatment Comparisons Proceedings of a Symposium, Heidelberg, Germany, 4th to 8th December, 1978
Ca. paper for requiring that any final publication of a trial should contain (among other analyses, perhaps) at least one report of the overall outcome in all patients allocated to each treatment group, irrespective of whether or not they actually received that treatment. (4) Finally, a less fundamental point but one whose implementation is unusual in that it yields obvious benefits for very little extra effort, people should be far more ready to consider "2 x 2" or other "factorial" trial designs.
0. •. I 5 I 10 X%: P = probability of more conservative treatment resulting in an X% decrease in 5 year rate. , (1972) Regression models and lifetables. R. (1978) The importance of beta, the type II error and sam~e size in the design and interpretation of the randomized control trial. New England Journal of Medicine, 299, 690-694 Peto, R. (1978) Private communication. R. (1973) Confidence limits in evaluating controlled therapeutic trials. Lancet, ii, 969-970 Comments to Dr. Haybittle's paper Dr.
Protocol Violations Because our entry criteria were minimal, there were no violations on this score (Table IV). On surgical technique, 10 patients in the radical mastectomy group were thought to have had doubtful clearance of the axilla and there was failure to identify a pectoral node in 28 patients in the simple mastectomy group. There were few errors in the radiotherapeutic techniques, only 8 patients not receiving the correct treatment. Two patients who had negative nodes received radiotherapy to the axilla, 5 patients who had positive nodes were not given radiotherapy in error, and 1 patient received too low a dose.
Clinical Trials in ‘Early’ Breast Cancer: Methodological and Clinical Aspects of Treatment Comparisons Proceedings of a Symposium, Heidelberg, Germany, 4th to 8th December, 1978 by Hans Scheurlen (auth.), H. R. Scheurlen, G. Weckesser, I. Armbruster (eds.)