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Clinical Trials: A Methodologic Perspective Second - download pdf or read online

By Steven Piantadosi

ISBN-10: 0471727814

ISBN-13: 9780471727811

ISBN-10: 0471740128

ISBN-13: 9780471740124

This publication is particularly exact. simple statistical ideas are in actual fact awarded yet basically these ideas which are very important in scientific trials. the writer offers the entire matters with medical trials together with moral concerns with a few ancient point of view. ideas of randomization and statistical layout are truly provided. It bargains dialogue of Bayesian innovations and meta-analyses, cross-over designs and staff sequential tools (interim analyses). For statisticians doing medical learn like myself, it is a invaluable reference resource.

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Extra info for Clinical Trials: A Methodologic Perspective Second Edition(Wiley Series in Probability and Statistics)

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Failure to master statistical concepts can lead to numerous and important errors and biases in medical research, a compendium of which is given by Andersen (1990). Coincident with this need for statistical knowledge in the clinic, it is necessary for the clinical trials statistician to master fundamental biological and clinical concepts relevant to the disease under study. Failure to accomplish this can also lead to serious methodological and inferential errors. A clinical researcher must consult the statistical expert early enough in the conceptual development of the experiment to improve the study.

In vitro studies on materials of human origin. These are studies using observational designs and blood, tissue, or other samples that attempt to show associations thought to be clinically important. Series of surgical or pathologic studies are often this type. 20 CLINICAL TRIALS AS RESEARCH 4. Models of human health and disease processes. , mathematical) models of disease, often used to guide laboratory and clinical investigations. 5. Field surveys. These are descriptive or analytic studies of risk factors or disease correlates in populations.

This reincarnated journal should be an excellent resource for trialists. A second helpful periodical source is Statistics in Medicine, which frequently has articles of interest to the trialist. It began publication in 1982 and is the official publication of the International Society for Clinical Biostatistics (mostly a European organization). These two societies have begun joint meetings every few years. Many papers of importance to clinical trials and related statistical methods appear in various other applied statistical and clinical journals.

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Clinical Trials: A Methodologic Perspective Second Edition(Wiley Series in Probability and Statistics) by Steven Piantadosi

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