Home Clinical • Download PDF by E. Horváth (auth.), E. Rajka, S. Korossy (eds.): Clinical Aspects of Immune Pathology

Download PDF by E. Horváth (auth.), E. Rajka, S. Korossy (eds.): Clinical Aspects of Immune Pathology

By E. Horváth (auth.), E. Rajka, S. Korossy (eds.)

ISBN-10: 1461572371

ISBN-13: 9781461572374

ISBN-10: 1461572398

ISBN-13: 9781461572398

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The functions of the complement system include [100]: immunological lysis of cells, destruction of bacteria, initiation of various stages of the inflammatory reaction, including increase in vascular permeability, production of chemotactic substances, enhancement of phagocytosis, promotion of blood coagulation, neutralization of viruses, and activation of bacterial lipopolysaccharides [259]. The mechanism of the sequential activation and inactivation of the complement system resembles, in its complexity, that of clot formation.

In the case of circulating haematological cells, however, some cell-sessile antibodies can also be demonstrated. e. the formation of specific rosettes around more than 6 of 1,000 lymphocytes [20, 102]. Significance of this technique in autoimmune haemolytic anaemia is a matter of debate [111 ], and care should be taken to avoid mistake for non-specific rosettes around sheep RBC apparently indicating human T lymphocytes. Some authors distinguish (i) complete antibodies (IgM cold agglutinins) easily demonstrated in saline, and (ii) incomplete (IgG) antibodies which are only demonstrable in a colloidal medium(= albumin or serum).

TABLE 44-IV Symptomatic immunohaemolytic anaemia with incomplete warm antibody (modified, after Gehrmann [97]) 1. So-called lymphoproliferative disorders: Lymphocytic leukaemia, lymphosarcoma and reticulosarcoma, Brill-Symmer's disease, myeloma, Waldenstrom's macroglobulinaemia Infectious mononucleosis 2. Systemic haematological disease other than ( 1 ): Chronic granulocytic leukaemia, monocytic leukaemia, myelofibrosis syndrome Pernicious anaemia 3. Systemic connective tissue disorders and presumably autoimmune diseases: Systemic lupus erythematosus, dermatomyositis, polyarteritis nodosa, Hashimoto's thyroiditis, colitis ulcerosa, multiple sclerosis, thymoma, rheumatic fever, rheumatoid arthritis 4.

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Clinical Aspects of Immune Pathology by E. Horváth (auth.), E. Rajka, S. Korossy (eds.)


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