By Branimir Ivan Sikic (auth.), C. Julian Rosenthal M.D., Marvin Rotman M.D. (eds.)
The first convention on concomitant infusion chemotherapy and radia tion treatment was once geared up with the purpose of bringing jointly a few of the investigators who've demonstrated, over the last few years, the hypo thesis that non-stop infusion chemotherapy may possibly modulate the cytotoxic impact of radiation remedy to the purpose of getting a strongly additive, if now not synergistic task on yes malignant tumors. This quantity represents the distinct lawsuits of this convention awarded in a manner that provides the reader a overview of the on-going re seek within the box. we've got under pressure a few matters from easy biologic study and impression of cellphone kinetics to the sensible equipment of drug supply platforms and early medical reports. the explanation for this new kind of mixed modality remedy has been offered through a few of its pioneers. Early scientific investigations in addition to the initial information of many who haven't but thoroughly matured have additionally been integrated. The reader should still examine those information with a few reser vations. eventually, those effects needs to be proven by means of higher potential randomized stories with right controls earlier than turning into accredited because the therapy of selection in in the neighborhood complicated tumors.
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Additional info for Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy
Mol. Pharmacol. 23:190-197, 1983. 22. M. A method for continuous drug infusion in unrestrained rats: its application in evaluating the toxicity of 5-fluorouracil/thymidine combination. J. Lab. Clin. Med. 93:1047-1053, 1979. 23. J. Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas. Cancer Res. 42:2930-2937, 1982. 24. A combination of 5-fluorouracil and thymidine in advanced colorectal carcinoma. Cancer Chemother. Pharmacol.
In this presentation, a metabolic modulation of FUra by dThd on dLCF that would offer the possibility of increasing the therapeutic efficacy of FUra in experimental systems and in patients with advanced colorectal carcinoma will be discussed. 29 MATERIALS AND METHODS FUra was obtained from Hoffman-La Roche, Inc. (Nutl ey ,NJ); Cal ci urn Leucovorin (folinic acid, dLCF) was supplied by Lederle Lab. (Pearl River, NY) and dThd was obtained from the National Cancer Institute (Bethesda, (vID). '-'--~FdUrd PRPPtransferase II 1"'-'--'1.
Combination clinical trials with thymidine and fluorouracil: a phase I and Glinical pharmacologic evaluation. Cancer 45:1135-1143, 1980. 35. T. Basis for natural variation in sensitivity to 5-fluorouracil in mouse and human cells in culture. Cancer Res. 39:383-390, 1979. 36. D:-Assessment of growth limiting events caused by 5-fluorouracil in mouse cells and in human cells. Cancer Res. 40:4113-4122, 1980. ). 42 EPIPODOPHYLLOTOXIN AND CISPLATIN ON CONTINUOUS INFUSION SCHEDULES Jacob J. Lokich Chief, Clinical Oncology New England Deaconess Hospital Harvard Medical School Boston, Massachusetts The Epipodophyllotoxins, VP16-213 and VM26, and the heavy metal cytotoxic agents, Cisplatin and its analogs, Spirogermanium and Gallium, represent two classes of agents which in clinical trials are traditionally delivered on an intermittent bolus schedule.
Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy by Branimir Ivan Sikic (auth.), C. Julian Rosenthal M.D., Marvin Rotman M.D. (eds.)