By G. J. Dockray, A. Varro (auth.), Professor Dr. med. Guido Adler, Privatdozent Dr. med. Christoph Beglinger (eds.)
A new presentation of physiological regulatory mechanisms and healing functions is given during this publication. It represents a set of the main updated details in cholecystokinin (CCK) learn, in particular concentrating on the advance and characterization of CCK antagonists. The ebook includes chapters at the synthesis, biochemical and pharmacological characterization of powerful and selective CCK antagonists in addition to physiological purposes of those compounds. The final portion of the publication is dedicated to the involvement of CCK in pathological states and capability scientific functions of CCK antagonists.
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Extra resources for Cholecystokinin Antagonists in Gastroenterology: Basic and Clinical Status
The active compound was purified and characterized, and named asperlicin. This was viewed as a 1,4-benzodiazepine with a large 3-substituent derived from tryptophan and leucine and a quinazolone fused to the 1,2 positions. At the time of discovery, this was the first antagonist to show selectivity for the CCK receptors from different tissues, thus confirming the presence of receptor subtypes. Through impressive insight, that group has been able to focus on the important component parts of this molecule to maintain activity, and, as a result of this, to develop a series of totally synthetic non-peptide CCK-receptor antagonists [2,5].
Polak JM, Pearse AGE, Heath CM (1975) Complete identification of endocrine cells in the gastrointestinal tract using semi thin-thin sections to identify motilin cells in human and animal intestine. Gut 16:225-229 Polak JM, Pearse AGE, Bloom SR, Buchan AMJ, Rayford PC, Thompson JC (1975) Identification of cholecystokinin-secreting cells. Lancet 2:1016-1017 Polak JM, Pearse AGE, Szelke M, Bloom SR, Hudson D, Facer P, Buchan AMJ, Bryant MG, Christofides N, Macintyre I (1977) Specific immunostaining of CCK cells by use of synthetic fragment antisera.
J. MILLER! Receptors which recognize cholecystokinin (CCK) peptides are particularly interesting and notable, both for their similarities and for their differences. eir structural specficities. Targets of CCK There are a large number of cell types which are targets for this family of hormones (CCK and gastrin). These are much more widespread than the classical targets for CCK, the pancreatic acinar cell and gallbladder muscularis smooth muscle cell, and for gastrin, the parietal cell. Additional potential targets include the brain, spinal cord, peripheral neural structures including many areas of the enteric plexuses, smooth muscle along the gut from esophagus to colon, endocrine cells along the gut and pancreas, chief cells, and various tumors such as small cell carcinomas and carcinoids.
Cholecystokinin Antagonists in Gastroenterology: Basic and Clinical Status by G. J. Dockray, A. Varro (auth.), Professor Dr. med. Guido Adler, Privatdozent Dr. med. Christoph Beglinger (eds.)