By C. I. Amos, W. Xu, M. R. Spitz (auth.), Prof. Dr. med. Hans-Jörg Senn, Dr. Alberto Costa M.D., Prof. M.D., Ph.D. V. Craig Jordan (eds.)
This quantity includes a part of the papers given on the moment annual convention of the newly based foreign Society of melanoma Chemoprevention held in August 1997 in St. Gallen, Switzerland. Pharmacologic intervention in human carcinogenes is in its very infancy, and the world over coordinated efforts to struggle the evolution of human cancers are just now taking form. this can be one of many first efforts to unite specialists of all significant teams and facilities world wide within the hugely attention-grabbing and thought-provoking box of chemoprevention of melanoma, specifically of the breast, colon and prostate.
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Extra resources for Chemoprevention of Cancer: A Clinical Update
In: Bronzetti G, Hayatsu H, De Flora S, Waters MD, Shankel DM (eds) Antimutagenesis and anticarcinogenesis mechanisms, vol III. Plenum Press, New York, pp 1-16 De Flora S, Balansky R, Bennicelli C, Camoirano A, D' Agostini F, Izzotti A, Cesarone CF (1995 a) Mechanisms of anticarcinogenesis: the example of N -acetylcysteine. In: Ioannides C, Lewis DFV (eds) Drugs, diet and disease, vol 1: Mechanistic approaches to cancer. Ellis Horwood, Hemel Hempstead, UK, pp 151-203 De Flora S, Cesarone CF, Balansky RM, Albini A, D' Agostini F, Bennicelli C, Bagnasco M, Camoirano A, Scatolini L, Rovida A, Izzotti A (1995b) Chemopreventive properties and 42 S.
Acta Odontol Scand 21:271-292 Stich HF, Rosin MP (1984) Micronuclei in exfoliated human cells as a tool for studies in cancer risk and cancer intervention. Cancer Lett 22:241-253 Stich HF, Stich W, Parida BB (1982) Elevated frequency of micronucleated cells in the buccal mucosa of individuals at high risk for oral cancer: betel quid chewers. Cancer Lett 17:125-134 Stich HF, Stich W, Rosin MP, Vallejera MO (1984) Use of the micronucleus test to monitor the effect of vitamin A, beta-carotene and canthaxanthin on the buccal mucosa of betel nut/tobacco chewers.
4 Favouring absorption of protective agents 2. 5 Killing of cells lacking tumour suppressor genes 3. 9 Inhibition of tumour necrosis factor a Rationale and Mechanisms of Cancer Chemoprevention 35 Table 1 (continued) 4. 8 Physical, chemical, or biological antineoplastic activity 5. 7 Activation of anti metastasis genes cations of mechanisms based on this concept have been also proposed (Kelloff and Boone 1994; Kelloff et al. 1994, 1996; Greenwald et al. 1995). The cascade of mechanisms shown in Table 1 should be interpreted in a flexible way, since several mechanisms are strictly interconnected or partially overlapping and important mechanisms, such as inhibition of genotoxic effects, antioxidant activity and scavening of free radicals, inhibition of cell proliferation, induction of cell differentiation, and signal transduction modulation, are reiterated several times in different phases of the process.
Chemoprevention of Cancer: A Clinical Update by C. I. Amos, W. Xu, M. R. Spitz (auth.), Prof. Dr. med. Hans-Jörg Senn, Dr. Alberto Costa M.D., Prof. M.D., Ph.D. V. Craig Jordan (eds.)