By S. J. Galli (auth.), Sudhir Gupta M.D., F.R.C.P.(C), F.A.C.P., Robert A. Good Ph.D., M.D. (eds.)
Impressive development has been made within the common box of immunology which has made attainable new figuring out and pragmatic ways to the sufferer with allergic disorder. certainly, one operating within the box of immunology senses a tremendous revolution of immunobiologic considering, a lot of which has relevance to the scientific perform of allergic reaction. To the training allergist, pediatrician, or internist who needs to care for allergic sufferers, the surging new info could appear complicated and bewildering. As a part of our entire sequence on glossy immunobiology which goals to digest this development, we think it really is applicable to dedicate a complete quantity to the elemental rules, new wisdom, and medical lore on which the trendy perform of allergic reaction has to be dependent. within the current quantity we try to assemble suitable contributions from leaders within the box of immunobiology with these whose paintings stands on the leading edge of medical perform. The advancing realizing has in different circumstances reached the purpose of medical program, and we now have attempted to surround during this quantity the full scope of contemporary allergy.
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Unpublished observations). In contrast, Theuson et ai. (1977, 1979) have demonstrated that a product of human mononuclear cell cultures does liberate histamine from basophils with rapid kinetics. Preliminary evidence indicates that the factor is a T-cell product recovered from the same gel-exclusion chromatographic fractions of culture supernatants as basophil chemotactic factor. These data offer additional support to the hypothesis that lymphocytes modulate basophil function in vivo. 5. 1. Basophil Anaphylactic Degranulation Exposure of the basophils of atopic patients to specific allergens results in a prompt and explosive discharge of granules along with their contained mediators such as histamine (Shelley and Juhlin, 1961).
Dvorak and Hirsch, 1971), dinitrochlorobenzene (H. , 1971), and syngeneic tumor cells (H. , 1973) may be elicited many weeks or months after the onset of immunization. While basophils are a prominent component of CBH reactions, there is no doubt that in many of these reactions T lymphocytes are essential to the induction and expression of this form of hypersensitivity just as they are in classical DH. Animals primed for CBH exhibit an expansion of the thymus-dependent paracortical zones of draining lymph nodes (A.
In typical guinea pig CBH reactions, basophils are present in concentrations of 300-600/linear mm skin surface and comprise 20-60% of infiltrating cells (Figure 7). This concentration is the more remarkable in that basophils normally account for less than 1% of circulating leukocytes, a fraction not significantly altered by usual techniques of immunization and skin testing. , 1976). However, this species may have up to 10 times as many circulating basophils as the guinea pig. In contrast, mature lesions of allergic contact dermatitis in man contain basophils, but these seldom exceed 200/linear mm and comprise <15% (often <5%) of the infiltrate (H.
Cellular, Molecular, and Clinical Aspects of Allergic Disorders by S. J. Galli (auth.), Sudhir Gupta M.D., F.R.C.P.(C), F.A.C.P., Robert A. Good Ph.D., M.D. (eds.)