By H. Seller, J. Czachurski, K. Dembowsky (auth.), Prof. Dr. W. Delius, Prof. Dr. E. Gerlach, Prof. Dr. H. Grobecker, Prof. Dr. W. Kübler (eds.)
An overseas Symposium "Catecholamines and the guts" used to be held in Munich in may well 1981, which used to be prepared in cooperation with the Council on Cardiac Metabolism of the overseas Society and Federation of Cardiology and with the Microcirculation operating crew of the ecu Society of Cardiology. It was once the purpose of the organizers to judge during this Symposium the new advances made within the box of sympathetic regulate of center functionality. specific awareness was once given to neural sympathetic pathways, to mechanisms and results of adrenoceptor stimulation and blockade in addition to to clinically correct implications ordinarily in regards to the value of catecholamines and of adrenoceptors in quite a few middle illnesses. The extensive scope was once coated in 34 papers offered through physiologists, pharmacologists and cardiologists in the course of a day assembly which used to be attended by way of a world viewers. This ebook contains all papers in addition to the discussions following each one presentation. to complete speedy e-book the manuscripts are released as submitted by means of the authors. The discussions have been edited applying the written questions and solutions of the discussants. The Symposium was once generously backed through Astra chemical compounds GmbH, Wedell Holstein, Germany, which hence made attainable a truly fruitful trade of knowledge, rules and ideas among experts in a variety of disciplines. The organizers gratefully recognize this help once more and want to thank Dr. T. Kreuzer, the consultant of Astra chemical compounds, for his own engagement.
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Extra resources for Catecholamines and the Heart: Recent Advances in Experimental and Clinical Research
Constantine JW, Weeks RA, McShane WK (1978) Prazosin and presynaptic a-receptors in the cardioaccelerator nerve of the dog. Eur J Pharmacol 50: 51-60 11. Crews FT, Smith CB (1978) Presynaptic alpha-receptor sub sensitivity after long-term antidepressant treatment. Science 202: 322-324 12. Dixon WR, Mosimann WF, Weiner N (1979) The role of presynaptic feedback mechanisms in regulation of norepinephrine release by nerve stimulation. J Pharmacol Exp Ther 209: 196-204 13. Docherty JR, McGrath JC (1979) An analysis of some factors influencing a-adrenoceptor feed-back at the sympathetic junction in the rat heart.
The best-studied ones, namely those that mediate an increase in the force of contraction, are surprisingly insensitive to noradrenaline in various heart preparations including human auric- 29 Table 1. Some responses mediated by myocardial a- and f3-adre- noceptors Contractile force Rate of beating Purkinje fiber action potential Atrial refractory period Atrial refractory period cAMP level a-Receptor f3-Receptor Increased In general unchanged Prolonged Increased Increased Shortened Prolonged Shortened Prolonged Shortened Unchanged Increased ular strips .
Variation in the total receptor pool seems at least partly to be responsible for the variation in potency of the full agonist isoprenaline and the maximal response to the partial agonist prenalterol observed in the rabbit papillary muscle. One week of treatment of cats with isoprenaline induced a reduction of the potency of isoprenaline and the maximal effect of prenalterol in the isolated papillary muscle. These changes were related to a decrease in the f3-adrenoceptor density in the cardiac muscle.
Catecholamines and the Heart: Recent Advances in Experimental and Clinical Research by H. Seller, J. Czachurski, K. Dembowsky (auth.), Prof. Dr. W. Delius, Prof. Dr. E. Gerlach, Prof. Dr. H. Grobecker, Prof. Dr. W. Kübler (eds.)