Home Biotechnology • New PDF release: Bioreactor Systems for Tissue Engineering

New PDF release: Bioreactor Systems for Tissue Engineering

By D. Wendt, S. A. Riboldi, M. Cioffi, I. Martin (auth.), Dr. Cornelia Kasper, Prof. Martijn van Griensven, Dr. Ralf Pörtner (eds.)

ISBN-10: 3540693564

ISBN-13: 9783540693567

The editors of this precise quantity may first wish to thank all authors for his or her very good contributions. we'd additionally prefer to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for supplying the chance to compose this quantity and Springer for organizational and technical help. Tissue engineering represents one of many significant rising fields in glossy b- know-how; it combines diverse topics starting from organic and fabric sciences to engineering and medical disciplines. the purpose of tissue engineering is the advance of healing methods to alternative diseased organs or tissues or enhance their functionality. as a result, 3 dimensional biocompatible fabrics are seeded with cells and cultivated in compatible structures to generate practical tissues. many alternative points play a task within the formation of 3D tissue constructions. within the first position the resource of the used cells is of the maximum significance. to avoid tissue rejection or immune reaction, preferentially autologous cells at the moment are used. particularly, stem cells from diversified assets are gaining unparalleled significance as they are often differentiated into diverse tissues by utilizing exact media and vitamins. within the box of biomaterials, a variety of scaffold fabrics exist already yet new composites also are being built in keeping with polymeric, common or xenogenic resources. in addition, a vital factor in tissue en- neering is the formation of tissues less than good outlined, managed and reprod- ible stipulations. for this reason, a considerable variety of new bioreactors were developed.

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Additional info for Bioreactor Systems for Tissue Engineering

Example text

1 A Muscle Tissue and Organ Bioreactor System What is a Muscle A whole muscle organ is a complex structure including cells and tissues of many types in addition to myofibers. Other cell types include adipocytes, fibroblasts or tenocytes, vascular smooth muscle, endothelium, and peripheral nerve. A whole muscle organ is also a “smart material” that can rapidly change its biochemical and mechanical properties over a wide range. A smart material is a material with properties that can be significantly altered and controlled by one or more external stimuli.

So far only engineered myocardial patches in animals-mostly ratsexist. The suitability of engineered heart tissue (EHT) depends on the degree of syncytoid tissue formation and cardiac myocyte differentiation in vitro, contractile function and electrophysiological properties. State of the art is still the Zimmermann and Eschenhagen [24] developed technology. The cardiac myocytes from neonatal rats were mixed with collagen I scaffold, cast in circular moulds, and subjected to phasic mechanical stretch, which leads to intensively interconnected, longitudinally oriented, cardiac muscle bundles.

Thompson CA, Colon-Hernandez P, Pomerantseva I, MacNeil BD, Nasseri B, Vacanti JP, Oesterle SN (2002) Tissue Eng 8:1083 33. Mol A, Driessen NJ, Rutten MC, Hoerstrup SP, Bouten CV, Baaijens FP (2005) Ann Biomed Eng 33:1778 34. Hahn MS, McHale MK, Wang E, Schmedlen RH, West JL (2007) Ann Biomed Eng 35:190 35. Hoerstrup SP, Zund G, Sodian R, Schnell AM, Grunenfelder J, Turina MI (2001) Eur J Cardiothorac Surg 20:164 36. Niklason LE, Gao J, Abbott WM, Hirschi KK, Houser S, Marini R, Langer R (1999) Science 284:489 26 D.

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Bioreactor Systems for Tissue Engineering by D. Wendt, S. A. Riboldi, M. Cioffi, I. Martin (auth.), Dr. Cornelia Kasper, Prof. Martijn van Griensven, Dr. Ralf Pörtner (eds.)

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