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Download e-book for kindle: Bioinformatics (Sequence and Genome Analysis) by David Mount

By David Mount

ISBN-10: 8123909985

ISBN-13: 9788123909981

Учебник по биоинформатике, а именно - по секвенированию ДНК и компьютерному анализу данных, полученных в результате такого секвенирования. Ну это, надо полагать, и из названия понятно По сути - это предельно простое введение в биоинформатику. Предназначено в первую очередь для биологов. Книга была написана на основе одноимённого курса, прочитанного автором в Университете Штата Аризона в 1999/2000 учебном году. В 2004 году вышло второе издание этой книжки. Здесь выложено первое издание, вышедшее в 2001 году.В ближайшее время выложу ещё несколько книжек по этой теме. Тогда добавлю сюда ссылки на эти раздачи.Образец страницы (уменьшено в four раза):

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B. The Hybridization Event The development of DNA biosensors requires proper attention to experimental variables affecting the hybridization event at the transducer-solution interface. These include the salt concentration, temperature, the presence of accelerating agents, viscosity, contacting time, base composition (%G + C), and length of probe sequence. Careful control of the hybridization event is thus required. The stability of duplexes formed between strands with mismatched bases is decreased according to the number and location of the mismatches.

Thus, for different experiments, the η-values should be monitored at identical time-intervals of the chronopotentiometric pulse. R′ = η/I = R′mod – R′Au (4) Several precautions and limitations should be mentioned upon the application of chronopotentiometry as an electrochemical method to analyze interface properties of layered-modified-electrodes, and, specifically, monolayer-functionalized-electrodes: (1) The chronopotentiometric pulse results in a potential shift on the electrode after the transition-time, τ, resulting in the discharge of the electrolyte.

18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 25 C. Y. Liang, E. G. Scalo, J. Chem. , 40, 919 (1964). R. S. Snart, Biopolymers, 6, 293 (1968). R. E. Holmlin, P. J. Dandliker, J. K. Barton, Angew. Chem. Int. , 36, 2714 (1997). S. O. Kelley, J. K. : A. Sigel, H. Sigel), Marcel Dekker, New York, 211 (1999). G. B. Schuster, Acc. Chem. , 33, 253 (2000). S. O. Kelley, R. E. Holmlin, E. D. A. Stemp, and J. K. Barton, J. Am. Chem. , 119, 9861 (1997). R. E. Holmlin, R.

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Bioinformatics (Sequence and Genome Analysis) by David Mount

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