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Bioinformatics in Cancer and Cancer Therapy by Christos A. Ouzounis (auth.), Gavin J. Gordon (eds.) PDF

By Christos A. Ouzounis (auth.), Gavin J. Gordon (eds.)

ISBN-10: 1588297535

ISBN-13: 9781588297532

ISBN-10: 1597455768

ISBN-13: 9781597455763

Bioinformatics will be loosely outlined because the assortment, type, garage, and research of biochemical and organic info utilizing pcs and mathematical algorithms. Bioinformatics represents a wedding of biology, medication, computing device technology, physics, and arithmetic; fields of analysis that experience traditionally existed as collectively specific disciplines. Edited by way of Gavin Gordon, Bioinformatics in melanoma and melanoma Therapy, edited by way of Gavin Gordon, presents an old and technical standpoint at the analytical concepts, methodologies, and structures utilized in bioinformatics experiments which will exhibit how a bioinformatics method has been used to represent numerous cancer-related techniques, and to illustrate how a bioinformatics process is getting used to bridge uncomplicated technological know-how and the scientific enviornment to definitely influence sufferer care and management.

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2003). , 1997). The transcriptome represents the multitude of RNA messages that encode the various proteins necessary to express the function of a gene. The term is often used to describe the sum total of all transcripts in the cell under specific biological conditions and is also used to describe all the possible transcripts under all possible conditions. Many more transcripts exist than the number of genetic loci that encode them. The study of the transcriptome will define the large picture of the functional cell.

It is the functional consequences of an inherited piece of DNA. Biologists now learn the central dogma of biology at an early age: DNA directs the transcription of RNA molecules, which in turn direct the translation of proteins (Fig. 1). These proteins produce activities that are ultimately observed as functional consequences for the cell or the organism. These phenotypes are the final measures that define genes. Therefore, the study of genes, which in recent times is referred to as “functional genomics,” involves all aspects of the study of cells and organisms, from the DNA itself to the outward characteristics that it encodes.

J Comput Biol 2005;10:119–42 Paik S, Shak S, Tang G, et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 2004;351:2817–26 Shih JH, Michalowska AM, Dobbin K, Ye Y, Qiu TH, Green JE. Effects of pooling mRNA in microarray class comparisons. Bioinformatics 2004;20:3318–25 Simon R. Roadmap for developing and validating therapeutically relevant genomic classifiers. J Clin Oncol 2005;23:7332–41 Simon RM, Dobbin K. Experimental design of DNA microarray experiments.

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Bioinformatics in Cancer and Cancer Therapy by Christos A. Ouzounis (auth.), Gavin J. Gordon (eds.)


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