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Lengauer T.'s Bioinformatics -From Genomes to Drugs PDF

By Lengauer T.

ISBN-10: 3527299882

ISBN-13: 9783527299881

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Additional resources for Bioinformatics -From Genomes to Drugs

Example text

The notion of molecular surface is not as much relevant, especially, since the ligand can be highly ¯exible and does not have a unique surface. In contrast, geometric complementarity of both proteins is a dominating issue in protein±protein docking, where both binding partners meet over a much larger contact surface area. Issues of desolvation can be essential here. e. subtle structural changes on the protein surface to accommodate binding are important in both problems, but seem to be more essential in protein±protein docking.

References 2 DeRisi, J. , V. R. Iyer, and P. O. Brown, Exploring the 3 4 5 6 7 8 9 10 metabolic and genetic control of gene expression on a genomic scale, Science, 1997. 278(5338): p. 680±6. , Berichte der Deutschen Chemischen Gesellschaft, 1894. 27: p. 2985±2993. Venter, J. , The Sequence of the Human Genome, Science, 2001. 291(5507): p. 1304±1351. Lander, E. , Initial sequencing and analysis of the human genome, Nature, 2001. 409(6822): p. 860±921. , Calculating nucleic acid secondary structure, Curr Opin Struct Biol, 2000.

680±6. , Berichte der Deutschen Chemischen Gesellschaft, 1894. 27: p. 2985±2993. Venter, J. , The Sequence of the Human Genome, Science, 2001. 291(5507): p. 1304±1351. Lander, E. , Initial sequencing and analysis of the human genome, Nature, 2001. 409(6822): p. 860±921. , Calculating nucleic acid secondary structure, Curr Opin Struct Biol, 2000. 10(3): p. 303±10. , Life with 6000 genes, Science, 1996. 274(5287): p. 546, 563±7. Genome sequence of the nematode C. elegans: a platform for investigating biology.

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Bioinformatics -From Genomes to Drugs by Lengauer T.


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