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Read e-book online Bioinformatics and Functional Genomics PDF

By Jonathan Pevsner

ISBN-10: 0471210048

ISBN-13: 9780471210047

The bestselling creation to bioinformatics and sensible genomics. Bioinformatics and useful Genomics deals the main broad-based creation to this explosive new self-discipline.

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Extra resources for Bioinformatics and Functional Genomics

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For example, a perspective on Chapter 2 (access to sequence information) is that the amount of DNA sequence data deposited in GenBank is undergoing an explosive rate of growth. In contrast, an area such as pairwise sequence alignment, which is fundamental to the entire field of bioinformatics (Chapter 3), was firmly established in the 1970s and 1980s. The pitfalls section of each chapter describes some common difficulties encountered by biologists using bioinformatics tools. Some errors might seem trivial, such as searching a DNA database with a protein sequence.

5. SwissProt numbers may also be a mixture of numbers and letters. They may contain other mixtures of numbers and letters (or numbers only). , 3973. A GenBank or RefSeq accession number refers to the most recent version of a given sequence. 2 is currently a RefSeq identifier for human RBP4. 2is the version number. By default, if you do not specify a version number then the most recent version is provided. 1 and you can learn about the revision history of that accession number. gov/entrez/query/static/help/helpdoc.

3). UniGene clusters are created by sequence similarity searching (see Chapters 3 and 4) using ESTs, and by gathering aligned sequences into clusters. Many clusters have only one member, representing unique sequences, while other clusters have tens of thousands of EST members. We will discuss UniGene clusters further in Chapter 6 (on gene expression). One might expect an equal number of UniGene clusters. However, in practice, there are more UniGene clusters than there are genes-currently, there are about 100,000 human UniGene clusters.

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Bioinformatics and Functional Genomics by Jonathan Pevsner

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