By Nikolai N. Korpan (auth.), Nikolai N. Korpan MD, PhD (eds.)
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28. Rewcastle Je, Sandison GA, Hahn LJ, Saliken Je, McKinnon IG, Donnelly BJ. A model for the time-dependent thermal distribution within an iceball surrounding a cryoprobe. Phys Med BioI 1998; 43 (12): 3519-3534. 29. Rewcastle IC, Sandison GA, Saliken JC, Donnelly BJ, McKinnon JG. Considerations during clinical operation of two commercially available cryomachines. JSurg Oncol 1999; 71 (2): 106-111. 30. Schuder G, Pistorius G, Fehringer M, Feifel G, Menger MD, Vollmar B. Complete shutdown of microvascular perfusion upon hepatic cryothermia is critically dependent on local tissue temperature.
The advantages of this method over traditional techniques are based on experimental and clinical experience. They are absence of tumor resistance to cryosurgical application, limited area of exposure, and monitoring of injurious effects of low temperatures on biological structures, presence of hemostatic and anesthetic effects, favorable course of a wound process following tissue cryolysis, and almost complete absence of general negative reactions of the organism. The practical value of the cryosurgical method is determined also by the possibility of treating neoplasms resistant to radiation and chemotherapy, to use it as a sparing treatment in elderly patients with concomitant diseases, and when tumors are located in surgically non-accessible areas.
1996). Thermomonitoring is especially important for normal tissues in the immediate proximity of a tumor, cold damage to which can lead to postoperative complications (for example, radical cryoablation of a prostate for a cancer). In that case the thermocouples, located on the periphery of the prostate, will provide the signal to stop freezing. The ultrasound control and thermocouples, placed on the periphery of the prostate, give a rather precise picture of the peripheral part of an ice ball, but the location of the isotherms and the condition of cells inside various zones of an ice ball remains unclear.
Basics of Cryosurgery by Nikolai N. Korpan (auth.), Nikolai N. Korpan MD, PhD (eds.)