By Lesley McGee, Keith P. Klugman (auth.), Douglas L. Mayers MD (eds.)
The volumes integrated in Antimicrobial Drug Resistance characterize the 1st finished, multidisciplinary reference overlaying the realm of antimicrobial drug resistance in micro organism, fungi, viruses, and parasites from easy technology, scientific, and epidemiological perspectives.
The first quantity, Antimicrobial Drug Resistance, Mechanisms of Drug Resistance, is devoted to the organic foundation of drug resistance and potent avenues for drug improvement. With the emergence of extra drug-resistant lines, the method of facing the drug resistance challenge needs to contain the study of other features of the mechanisms of bacterial resistance and the dissemination of resistance genes in addition to study using new genomic info. those methods will enable the layout of novel thoughts to strengthen new antibiotics and safeguard the effectiveness of at the moment on hand ones.
The moment quantity, Antimicrobial Drug Resistance, scientific and Epidemiological Aspects, is dedicated to the scientific elements of drug resistance. even if there's proof that limited use of a particular antibiotic might be via a reduce in drug resistance to that agent, drug resistance keep an eye on isn't really simply accomplished. hence, the infectious disorder health care professional calls for enter from the scientific microbiologist and an infection keep an eye on expert to make educated offerings for the potent remedy of assorted lines of drug-resistant pathogens in person patients.
This 2-volume set is a vital reference for college kids in microbiology, infectious ailment physicians, clinical scholars, simple scientists, drug improvement researchers, microbiologists, epidemiologists, and public future health practitioners.
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Additional info for Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects
Quinupristin–dalfopristin resistance in Streptococcus pneumoniae: novel L22 ribosomal protein mutation in two clinical isolates from the SENTRY antimicrobial surveillance program. Antimicrob Agents Chemother 2003;47:2696–2698 Schmitz FJ, Perdikouli M, Beeck A, Verhoef J, Fluit AC. Molecular surveillance of macrolide, tetracycline and quinolone resistance mechanisms in 1191 clinical European Streptococcus pneumoniae isolates. Int J Antimicrob Agents 2001;18:433–436 Jones ME, Blosser-Middleton RS, Thornsberry C, Karlowsky JA, Sahm DF.
A low occurrence of telithromycin-nonsusceptible pneumococci has also been reported in other studies (111, 112). Thus, although ketolide resistance is rare, resistant isolates have nonetheless been documented. Mutations in the resistance determinant erm(B) have been suggested to confer telithromycin resistance (112, 113). In addition, mutations at macrolide and ketolide binding sites, such as domains II and V of 23S rRNA and ribosomal proteins L4 and L22, have been reported to be associated with an elevated telithromycin MIC (113).
Balsalobre L, Ferrandiz MJ, Linares J, Tubau F, de la Campa AG. Viridans group streptococci are donors in horizontal transfer of toposiomerase IV genes to Streptococcus pneumoniae. Antimicrob Agents Chemother 2003;47:2072–2081 108. Bast DJ, de Azavedo JC, Tam TY, et al. Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother 2001;45:2631–2634 109. Pletz MWR, McGee L, Beall B, Whitney CG, Klugman KP. Interspecies recombination in type II topoisomerase genes is 691 110.
Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects by Lesley McGee, Keith P. Klugman (auth.), Douglas L. Mayers MD (eds.)