By Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. (Hon.), Peter Zahradka Ph.D., Ian M. C. Dixon Ph.D., Robert E. Beamish M.D. (eds.)
The courting among angiotensin II and high blood pressure was once tested in 1898 while angiotensin II used to be proven to modulate systemic blood strain. Over the intervening a long time, a whole characterization of the renin-angiotensin process (RAS) has been accomplished, and our figuring out of its biochemistry and body structure has resulted in the directed improvement of brokers such ·as ACE inhibitors and receptor antagonists able to controlling high blood pressure. extra lately, it used to be proven that angiotensin II is secreted inside of definite tissues and that those tissue-specific structures function independently of the systemic RAS. the unconventional idea that angiotensin II regulates a few cardiovascular procedures which are unrelated to blood strain has renewed the curiosity of either easy and medical scientists in angiotensin II. The organization among angiotensin II and cardiac development, specifically, has indicated that remedies presently in use for high blood pressure can have direct program to the remedy of center failure. The Manitoba Cardiovascular discussion board on Angiotensin Receptor Blockade in Winnipeg used to be convened October 18-20, 1996 to check the medical and simple features of angiotensin receptor biology as they practice to high blood pressure and center failure. furthermore, the aptitude therapy of those stipulations utilizing particular angio tensin receptor antagonists used to be addressed in the context in their instant healing software and destiny potential.
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Extra info for Angiotensin II Receptor Blockade Physiological and Clinical Implications
Angiotensin clearly had contributed to the overall renal response, including sodium retention. In general, it appeared that pharmacological interruption had not entirely reversed the renal response in these settings. It was likely, under these circumstances, that an additional effector system or systems may have contributed a direct action of the sympathetic nerves on the renal blood supply, or it may be a reflection of reduced arterial perfusion pressure during pharmacological interruption of the renin system.
ASN Program Abstract #A0591 from 29th Annual Meeting in New Orleans. J Am Soc Nephrology 7:163. THE BRAIN RENIN-ANGIOTENSIN SYSTEM AND SALT-SENSITIVE HYPERTENSION SHEREENI J. H. LEENEN University ~ Ottawa Heart Institute, Ottawa, Ontario, Canada Summary. An intrinsic tissue renin-angiotensin system (RAS) has been described in the brain. This review provides an overview of the localization of the enzymes, peptides, and receptors of the brain RAS and the organization of angiotensinergic pathways involved in cardiovascular regulation.
This conference was sponsored by the International Society and Federation of Cardiology and the International Academy of Cardiovascular Sciences for promoting the scientific basis of cardiology. The help provided by Dr. Garry Ross in having this Conference recognized under the MRC/PMAC Program is highly appreciated. The collaboration of Mr. Ivan Berkowitz of Winnipeg in coordinating all events associated with this meeting is gratefully acknowledged. It would have been virtually impossible to organize this Conference without the cooperation and hard work of Ms.
Angiotensin II Receptor Blockade Physiological and Clinical Implications by Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. (Hon.), Peter Zahradka Ph.D., Ian M. C. Dixon Ph.D., Robert E. Beamish M.D. (eds.)