By Itzhak Brook
With new infectious brokers, antibiotics, and cases of antimicrobial resistance regularly at the horizon, this box is an ever becoming self-discipline that calls for consistent vigilance. This publication responds to burgeoning progress within the box and gives a complete and professional armamentarium of directions for the therapy and analysis of the total breadth of grownup and pediatric anaerobic infections.
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Hopkins MJ, Macfarlane GT, Furrie E, Fite A, Macfarlane S. Characterisation of intestinal bacteria in infant stools using real-time PCR and northern hybridisation analyses. FEMS Microbiol Ecol 2005; 54:77–85. 43. Rotimi VO, Cuerden BI. The development of the bacterial ﬂora in normal neonates. J Med Microbiol 1981; 14:51–62. 44. Bullen CL, Tearle PV. Biﬁdobacteria in the intestinal tract of infants: an in vitro study. J Med Microbiol 1976; 9:335–44. 45. Stark PL, Lee A. The microbial ecology of the large bowel of breast and formula-fed infants during the ﬁrst year of life.
The esophagus, stomach, duodenum, jejunum, and proximal ileum normally contain relatively few bacteria. However, the ﬂora becomes more complex and the number of different bacterial species increases in the distal portions. Even though the stomach is constantly seeded with oropharyngeal organisms (22), the gastric acidity decreases their number. Those who receive acid reducing medications, or suffer from gastric bleeding have a higher pH, and subsequently more surviving bacteria (23). The bacterial counts in the small intestine are relatively low, with total counts of 102 to 105 aerobic and anaerobic organisms per milliliter.
Brook I. Bacteremia caused by anaerobic bacteria in children. Crit Care 2002; 6:205–11. 3. Brook I. Bacterial interference. Crit Rev Microbiol 1999; 25:155–72. 4. Brook I, Frazier EH. Aerobic and anaerobic bacteriology of wounds and cutaneous abscesses. Arch Surg 1990; 125:1445–51. 5. Evans CA, Smith WM, Johnson EA, Gilbert ER. Bacterial ﬂora of the normal human skin. J Invest Dermatol 1950; 15:305–24. 6. McGinley KJ, Webster GF, Ruggieri MR, Leyden JJ. Regional variation in density of cutaneous Propionibacterium: correlation of Propionbacterium acnes populations with sebaceous secretions.
Anaerobic Infections: Diagnosis and Management by Itzhak Brook