By Frederick R. Appelbaum MD (auth.), Mary J. Laughlin MD, Hillard M. Lazarus MD (eds.)
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Extra info for Allogeneic Stem Cell Transplantation: Clinical Research and Practice
N Engl J Med 1984;311:812–818. 11. Keating MJ, Smith TL, Kantarjian H, et al. Cytogenetic pattern in acute myelogenous leukemia: a major reproducible determinant of outcome. Leukemia 1988;2:403–412. Chapter 2 / Allogeneic BMT for AML 25 12. Mrozek K, Heinonen K, de la Chapelle A, Bloomfield CD. Clinical significance of cytogenetics in acute myeloid leukemia. Semin Oncol 1997;24:17–31. 13. Fenaux P, Chastang C, Chevret S, et al. A randomized comparison of all-transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of maintenance therapy in newly diagnosed acute promyelocytic leukemia.
Hematopoietic Cell Transplantation, 2nd ed. Blackwell Science, London, 1999, pp. 287–295. 49. Miller CB, Rowlings PA, Zhang MJ, et al. The effect of graft purging with 4-hydroperoxycyclophosphamide in autologous bone marrow transplantation for acute myelogenous leukemia. Exp Hematol 2001;29:1336–1346. 50. Appelbaum FR, Clift RA, Buckner CD, et al. Allogeneic marrow transplantation for acute nonlymphoblastic leukemia after first complete relapse. Blood 1983;61:949–953. 51. Buckner CD, Clift RA, Thomas ED, et al.
There was an 18% response rate to DLI seen in the ALL group in contrast to 60% seen in the CML group (68). Direct and indirect evidence suggests that donor T cells and natural killer (NK) cells are primary mediators of GVL after DLI, but the target antigens on the tumor cells are currently poorly defined. The disease specificity exhibited by DLI suggests that the target antigens of GVL may be tumor-specific. There may be differences in the ability of ALL cells to present Chapter 3 / Stem Cell Transplantation for ALL 41 Table 5 Risk of Relapse Following Non-T Cell-Depleted Allogeneic Transplantation in Adult ALL Study No.
Allogeneic Stem Cell Transplantation: Clinical Research and Practice by Frederick R. Appelbaum MD (auth.), Mary J. Laughlin MD, Hillard M. Lazarus MD (eds.)