Home Bioinformatics • Download PDF by Jan Vijg: Aging of the Genome: The Dual Role of DNA in Life and Death

Download PDF by Jan Vijg: Aging of the Genome: The Dual Role of DNA in Life and Death

By Jan Vijg

ISBN-10: 019856922X

ISBN-13: 9780198569220

ISBN-10: 0198569238

ISBN-13: 9780198569237

Getting older has lengthy on account that been ascribed to the sluggish accumulation of DNA mutations within the genome of somatic cells. despite the fact that, it is just lately that the mandatory refined know-how has been constructed to start checking out this thought and its outcomes. Vijg seriously studies the idea that of genomic instability as a potential common reason for getting older within the context of a brand new, holistic realizing of genome functioning in complicated organisms due to fresh advances in practical genomics and platforms biology. It offers an up to date synthesis of present learn, in addition to a glance forward to the layout of suggestions to retard or opposite the deleterious results of getting older. this can be relatively vital in a time after we are urgently attempting to resolve the genetic portion of aging-related illnesses. furthermore, there's a turning out to be public reputation of the significant of knowing extra in regards to the underlying biology of getting older, pushed via carrying on with demographic swap.

Show description

Read or Download Aging of the Genome: The Dual Role of DNA in Life and Death PDF

Similar bioinformatics books

Download PDF by Peter Clote: Computational Molecular Biology: An Introduction

Quite often I believe the 2 earlier studies. This ebook isn't very strong as an creation. First learn another booklet reminiscent of Setubal and Meidanis, "Introduction to Computational Molecular Biology"; or Krane & Raymer, "Fundamental recommendations of Bioinformatics". those books have extra readable narrative and examples.

New PDF release: Advances in Mass Data Analysis of Signals and Images in

This publication constitutes the refereed complaints of the overseas convention on Mass facts research of signs and pictures in drugs, Biotechnology and Chemistry, MDA 2006 and 2007, held in Leipzig, Germany. . the themes contain innovations and advancements of sign and picture generating strategies, item matching and item monitoring in microscopic and video microscopic pictures, 1D, second and 3D form research, description and have extraction of texture, constitution and site, snapshot segmentation algorithms, parallelization of photo research and semantic tagging of pictures from lifestyles technology functions.

Genomics: Essential Methods by Mike Starkey, Ramnath Elaswarapu PDF

Genomics study has made major advances lately. during this ebook, a crew of internationally-renowned researchers percentage the main up to date info in a box that has in recent times switched emphasis from gene identity to practical genomics and the characterization of genes and gene items.

Download PDF by Jose M. Alonso, Anna N. Stepanova: Plant Functional Genomics: Methods and Protocols

This moment variation volumediscusses the innovative improvement of quicker and cheaper DNA sequencing applied sciences from the prior 10 years and makes a speciality of common applied sciences that may be used by a wide range of plant biologists to deal with particular questions of their favourite version structures.

Additional resources for Aging of the Genome: The Dual Role of DNA in Life and Death

Example text

In reality, biological characteristics involve complex interactions among many components in cells, such as DNA, RNAs, proteins, and small molecules. Emphasizing this integrative nature of biological function, Hartwell and Hopfield coined the term functional modules41. In functional genomics, a distinction is made between the different levels of organization in the cell. The genome, as we have seen, denotes the totality of all genes on all chromosomes in the nucleus of a cell. The complete set of mRNAs, the next hierarchical level below the genome, is called the transcriptome.

At this point in time, there are hundreds of mutant genes in a variety of organisms, from yeast and fruit flies to mice, which increase longevity by dampening growth, reproduction, energy metabolism, or nutrient sensing. There are also mutant genes that cause accelerated aging, but these are not always generally accepted due to the difficulties in demonstrating that reduced longevity is genuinely due to accelerated aging or merely a result of a disease or developmental defect. This is discussed extensively in Chapter 5.

A central component of functional genomics, driven by high-throughput methods and information science, is the ability to standardize extensive sets of disparate data. A key attribute in standardizing biological databases, which makes them computationally accessible, is an ontology. An ontology formally defines a common set of terms that are used to describe and represent a domain. Such vocabularies of terms specify the concepts in a given field and avoid semantic confusion. An example is the Gene Ontology, which can be used to describe the biological process, molecular function, and cellular location of any gene product.

Download PDF sample

Aging of the Genome: The Dual Role of DNA in Life and Death by Jan Vijg


by David
4.1

Rated 4.40 of 5 – based on 21 votes

Author:admin