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Read e-book online Aging and Cell Function PDF

By Richard G. Cutler (auth.), John E. Johnson Jr. (eds.)

ISBN-10: 1475714300

ISBN-13: 9781475714302

ISBN-10: 1475714327

ISBN-13: 9781475714326

The getting older technique, like so much (all?) issues within the universe, is a puzzle. it's this kind of basic prevalence, universal to all residing issues, that it sarcastically could be the most complex and confusing puzzle to resolve. There are, in fact, puzzles adequate in quantity to occupy the entire scientists and philosophers who've ever lived one thousand instances over. but what different phenomenon impacts every person people up to getting older? interest concerning the ubiquity of getting older as a phenomenon, boosted probably by way of an purely typical worry of that very same phenomenon as an indisputable manifes­ tation of our personal mortality, has ended in the compilation of information at the getting older strategy, that have amassed as quickly because the aged who could gain advantage from these facts. lots of the medical facts at the biology of getting older are on the biochemical and physiological degrees, whereas relatively little details has been avail­ capable on the anatomical point. due to this, a two-volume set referred to as getting older and mobile constitution used to be conceived, the 1st quantity having been released in 1981 and the second one quantity being released simultaneously with the current one on cellphone functionality. The emphasis on education of scientists and different contributors in complex schooling has, in the course of prior a long time, been certainly one of elevated specialization. now not simply will we concentrate on body structure, anatomy, zoology, or literature, yet in glomerular filtration, synaptic junctions, tree frogs of Brazil, or English poetry of the 19th century.

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Instead, it is proposed that aging processes are separate from those determining LSP. Thus, a study of the biological basis of longevity of mammalian species, as opposed to aging, represents a completely new approach to arrive more directly and efficiently at practical applications to extend lifespan and reduce the many detrimental effects of old age. The study of the biological basis of longevity was first undertaken in a systematic manner by George Sacher (Sacher, 1959, 1960a,b, 1962, 1965, 1966, 1968, 1970).

1980). This latter observation may be quite important, for the age-dependent decrease in fluidity (increase in viscosity) has been shown to modulate the binding of serotonin. Thus, changes in this type of membrane property could change a cell's response to specific hormones by altering receptor binding site availability. This might be what is occurring when a loss of hormone receptor is found. Also, such changes would be consistent with dysdifferentiation occurring in these cells. Changes in membrane fluidity could be a result of a change in the relative amount of its constituents.

This is shown by the appearance of new cell functions, such as the synthesis of foreign proteins, extopic hormone-producing tumors (Samaan, 1979), the loss in sensitivity to normal controlling elements of cell division, altered patterns of isoenzymes (Criss, 1971; Schapira, 1973; Knox, 1976), and changes in properties of the cell membrane (Cone, 1971, 1974, 1980; Cone and Cone, 1978). It is also well known that the probability of cancer appearing as a function of time increases with an individual's age.

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Aging and Cell Function by Richard G. Cutler (auth.), John E. Johnson Jr. (eds.)

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