Home Nonfiction 10 • Advances in Peptic Ulcer Pathogenesis by A. Sonnenberg, A. Sengupta, P. Bauerfeind (auth.), W. D. W. PDF

Advances in Peptic Ulcer Pathogenesis by A. Sonnenberg, A. Sengupta, P. Bauerfeind (auth.), W. D. W. PDF

By A. Sonnenberg, A. Sengupta, P. Bauerfeind (auth.), W. D. W. Rees MD, MRCP (eds.)

ISBN-10: 9400912455

ISBN-13: 9789400912458

ISBN-10: 9401070520

ISBN-13: 9789401070522

Over the earlier decade loads of examine task has happened on each side of the gastroduodenal epithelial interface, with the typical target of elucidating the mechanisms of mucosal safeguard and the way those can be compromised in peptic ulcer sickness. a major stimulus to such study has been the belief that irregular acid secretion or its supply into the duodenum in over the top quantity can't absolutely clarify ulcer pathogenesis within the majority of sufferers. One might envisage the tummy and proximal duodenum as being in a dynamic equilibrium, with competitive luminal elements, akin to acid and pepsin, being counteracted by means of protecting mucosal mechanisms. till lately, the mechanisms interested by mucosal safeguard were poorly outlined whereas the body structure and pathophysiology of acid and pepsin secretion were elucidated. The effect that gastroduodenal mucosa was once safe by way of a unmarried mechanism has ultimately been changed by means of a extra reasonable view, suggesting a couple of protecting zones appearing in sequence. a few of these zones may possibly act as first or moment line defences opposed to competitive components whereas yes zones could particularly guard opposed to sure aggressors.

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Advances in Peptic Ulcer Pathogenesis by A. Sonnenberg, A. Sengupta, P. Bauerfeind (auth.), W. D. W. Rees MD, MRCP (eds.)


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