By H. Rahn (auth.), Hermann Rahn Ph.D., Omar Prakash M.D. (eds.)
During the final two decades teams of investigators have involved themselves with the matter of acid-base legislation at quite a few physique temperatures. every one staff, in expert isolation, pursued a separate direction. Surgeons and anesthe tists constructed suggestions and instruments for hypothermic cardio-pulmonary by-pass operations and dependent their purpose for acid-base administration on in vitro types of blood habit. Physiologists and biochemists, nevertheless, endeavored to appreciate acid-base rules in residing organisms clearly subjected to adjustments in physique temperature. simply within the final decade has there been an expanding information that every workforce may gain advantage from the other's reports. With this target in brain individuals of either teams have been invited to offer their perspectives and observations within the wish of arriving at a greater figuring out of acid-base administration in the course of hypothermia and gaining a better perception into the criteria which keep watch over acid-base rules in the course of normothermia. This ended in the presen tation of the current quantity with the purpose of offering the clinician with a survey of current theories and the ensuing thoughts for administration of the hypother mic sufferer. Acknowledgment The editors exhibit their nice appreciation to overlook Augusta Dustan for her committed attempt within the coaching and modifying of the manuscripts. participants Heinz Becker, M. D. division of surgical procedure, collage of California clinical heart, Los An geles, l. a., CA 90024, U. S. A. Gerald D. Buckberg, M. D. division of surgical procedure, collage of California scientific heart, Los An geles, CA 90024, U. S. A.
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Additional resources for Acid-Base Regulation and Body Temperature
This approach to acidbase control is unavoidably associated with long transient imbalance states. Figure 10 graphically summarizes the control of acid-base balance based on data from a large number of ectothermic vertebrates, both air- and waterbreathers: fishes, amphibians and reptiles. 8 in whole blood independent of body temperature. This means that the actively regulated blood pH (to maintain (pH - pKIm ) constant) is different at each body temperature. In general these regulatory features may be viewed as mechanisms that permit a species to change body temperature without changing protein net charge state.
J Appl Physiol40: 752-761, 1976. 3. Reeves RB: Temperature-induced changes in blood acid-base status: Donnan rCi and red cell volume. 1 Appl Physiol40: 762-767,1976. 4. Matthew lB, Hanania G, Gurd FRN: Electrostatic effects in hemoglobin: hydrogen ion equilibria in human deoxy- and oxyhemoglobin A. Biochemistry 18: 1919-1927, 1979. 5. Reeves RB, Rahn H: Patterns in vertebrate acid-base regulation. In: Evolution of Respiratory Processes: A Comparative Approach. Wood Sand Lenfant C (eds). : 225-252.
Physiol. 49: 205-222, 1982. 12. Rosenthal TB: The effect of temperature on the pH of blood and plasma in vitro 1. BioI. Chern. 173: 25-30, 1948. 13. Roos A, Boron WF: Intracellular pH. Physiol. Rev. 61: 296-434, 1981. 14. Reeves RB: Alphastat regulation of intracellular acid-base state? Proc. 1st. Int. Congr. Compo Physiol. Biochem. (in press). 3. Acid-base regulation during hibernation A. MALAN Abstract The 'constant pH' strategy of hibernators involves loading considerable amounts of CO 2 during the entrance into hibernation, and hyperventilating to eliminate this CO 2 during the arousal.
Acid-Base Regulation and Body Temperature by H. Rahn (auth.), Hermann Rahn Ph.D., Omar Prakash M.D. (eds.)